L. Garneau, C. Aguer. Role of myokines in the development of muscle insulin resistance and related metabolic defects in type 2 diabetes. 2019. In press.
E. Guérin, H. Jaafar, L. Amrani, D. Prud'homme, C. Aguer. Intervention strategies to prevent comorbid depression among individuals with type 2 diabetes: a scoping review. Frontiers in Public Health. 2019. 5:7-35.
L. Nadeau, C. Aguer. Reply to “Discussion of ‘Interleukin-15 as a myokine: mechanistic insight into its effect on skeletal muscle metabolism’ -- Interleukin-15 and interleukin-15Rα-dependent/-independent functions in human skeletal muscle are largely unknown”.Applied Physiology, Nutrition, and Metabolism. 2019. 44(3):338-339
C. Tremblay Laganière, L. Garneau, J.F. Mauger, V. Peshdary, E. Atlas, A.S. Nikolla, N.A. Chapados, C. Aguer. Polychlorinated biphenyl 126 exposure in rats alters skeletal muscle mitochondrial function. Environ Sci Pollut Res. 2019. 26(3):2375-2386.
L. Nadeau, D.A. Patten,A. Caron, L. Garneau, E. Pinault-Masson, M. Foretz, P. Haddad, B.G. Anderson, L. Quinn, K. Jardine, M. McBurney, E.E. Pistilli, M.E. Harper, C. Aguer. IL-15 improves skeletal muscle oxidative metabolism and glucose uptake in association with increased respiratory chain supercomplex formation and AMPK pathway activation. BBA General Subject. 2019. 1863:395-407.
L. Nadeau, C. Aguer. Interleukin-15 as a myokine: effects on skeletal muscle metabolism and mechanistic insights. Invited review in Applied Physiology, Nutrition, and Metabolism. 2019. 44(3):229-238.
K. Lambert, C. Aguer, M. Kitzmann, A. Mannarino, C. Fédou, E. Raynaud De Mauverger, J. Mercier, J-F. Brun. Whole-body lipid oxidation during exercise is correlated to insulin sensitivity and mitochondrial function in middle-aged obese men. Austin Diabetes Research. 2017. 2(1):1013.
C. Dubé, C. Aguer, K. Adamo, S. Bainbridge. A role for maternally derived myokines to optimize placental function and fetal growth across gestation. Applied Physiology, Nutrition, and Metabolism. 2017. In press.
D.P. Blondin, A. Daoud, T. Taylor, H. Tingelstad, V.Bézaire, D. Richard, A.C. Carpentier, A.W. Taylor, M.-E. Harper, C. Aguer$, F. Haman$. Four-weeks of cold acclimation in adult humans shifts the ATPase-independent source of heat production from skeletal muscle to BAT. J Physiol. 2017. 595(6):2099-2113. $indicates co-corresponding authors.
C. Aguer$, B. Piccolo$, O. Fiehn, S.H. Adams, M.E. Harper. Untargeted metabolomics uncovers a novel amino acid signature from exercised mice overexpressing muscle uncoupling protein 3. 2017. 31(2):814-827. $indicates co-first authors.
L. Chehade$, A. Caron$, C. Aguer. Persistent organic pollutants: potential role in the development of insulin resistance and mitochondrial dysfunction in skeletal muscle.Environment and Natural Resources Research. 2016. 6 (4).$indicates co-first authors.
J.F. Mauger$ , L. Nadeau$, A. Caron, N.A. Chapados,C. Aguer. Polychlorinated biphenyl 126 exposure in L6 myotubes alters glucose metabolism: a pilot study. Environ Sci Pollut Res Int. 2016. Mar 2. $indicates co-first authors.
O. Gavarry, C. Aguer, A. Delextrat, G. Lentin, K. Ayme, A. Boussuges. Severely obese adolescent girls rely earlier on carbohydrates during walking than normal-weight matched girls. Journal of Sport Sciences. 2015. 11:1-10.
C. Aguer, C.S. McCoin, T.A. Knotts, A.B. Thrush, K.D. Ono-Moore, R. McPherson, R. Dent, D. Hwang, S.H. Adams, M.E. Harper.Acylcarnitines: potential implications for skeletal muscle insulin resistance. Faseb J. 2015. 29(1): 336-45.
C. Aguer, O. Fiehn, E.L. Seifert, V. Bézaire, J.K. Meissen, A. Daniels*, K. Scott, J.M. Renaud, M. Padilla, D.R. Bickel, M. Dysart, S.H. Adams, M.E. Harper. Muscle UCP3 overexpression mimics endurance training in revealing circulating biomarkers of beta-oxidation. Faseb J. 2013 Oct;27(10):4213-25.
C. Aguer, M. Pasqua, C. Moffat, M. McBurney, K. Jardine, R. Zhang, B. Beauchamps, R. Dent, R. McPherson, M.E. Harper.Increased antioxidant defenses in myotubes from obese non-diabetic subjects with a family history of type 2 diabetes. BBA Molecular Basis of Disease. 2013. 1832(10):1624-1633.
C. Aguer, M.E. Harper. Skeletal Muscle Mitochondrial Energetics in Obesity and Type 2 Diabetes Mellitus: Endocrine Aspects. Best Pract Res Clin Endocrinol Metab. 2012. 26(6):805-19.
E.L. Seifert, M. Bastianelli, C. Aguer, C. Moffat, C. Estey, L.G. Koch, S.L. Britton, M.E. Harper. Intrinsec aerobic capacity correlates with inherent mitochondrial oxidative and H2O2 emission without major shifts in myosin heavy chain isoform. J Appl Physiol. 2012. 113(10):1624-34.
C. Estey, E. L. Seifert, C. Aguer, C. Moffat, M.E. Harper. Effects of calorie restriction in mice overexpressing UCP3: evidence that adaptations to calorie restriction and mitochondrial uncoupling depend on distinct mechanisms. Exp Gerontol. 2012. 47(5):361-71.
C. Aguer, D. Gambarotta, R.J. Mailloux, C. Moffat, R. Dent, R. McPherson, M.E. Harper. Galactose Enhances Oxidative Metabolism and Reveals Mitochondrial Dysfunction in Human Primary Muscle Cells. PLoS One. 2011. 6(12):e28536.
C. Aguer, M. Foretz, L. Lantier, S. Hebrard, B. Viollet, J. Mercier, M. Kitzmann. Increased FAT/CD36 cycling and lipid accumulation in myotubes derived from obese type 2 diabetic patients. PLoS One. 2011. 6(12):e28981.
R. J. Mailloux, T. Dumouchel, C. Aguer, R. deKemp, R. Beanlands, M.E. Harper. Hexokinase II acts through UCP3 to suppress mitochondrial reactive oxygen species production and maintain aerobic respiration. Biochem J. 2011. 437(2):301-11.
R. J. Mailloux, E.L. Seifert, F. Bouillaud, C. Aguer, S. Collins, M.E. Harper. Glutathionylation acts as a control switch for uncoupling proteins UCP2 and UCP3. J Biol Chem, 2011. 286(24):21865-75.
M. Kitzmann,L. Lantier,S. Hébrard,J. Mercier, M. Foretz,C. Aguer. Abnormal metabolism flexibility in response to high palmitate concentrations in myotubes derived from obese type 2 diabetic patients. BBA Molecular Basis of Disease. 2011. 1812(4):423-30.
S.A. Crawford, S.R. Costford, C. Aguer, S.C. Thomas, R.A. deKemp, J.N. DaSilva, D. Lafontaine, M. Kendall, R. Dent, R.S. Beanlands, R. McPherson, M.E. Harper. Naturally occurring R225W mutation of the gene encoding AMP-activated protein kinase (AMPK)gamma(3) results in increased oxidative capacity and glucose uptake in human primary myotubes. Diabetologia. 2010. 53(9):1986-97.
C. Aguer, J. Mercier, C.Y. Man, L. Metz, S. Bordenave, K. Lambert, E. Jean*, L. Lantier, L. Bounoua, J.F. Brun, E. Raynaud de Mauverger, F. Andreelli, M. Foretz, M. Kitzmann. Intramyocellular lipid accumulation is associated with permanent relocalisation ex vivo and in vitro of fatty acid translocase (FAT)/CD36 in obese patients. Diabetologia. 2010. 53(6):1151-63.
C. Aguer, O. Gavarry, Y. Gole, A. Boussuges, P. Doyard, G. Falgairette. A 5-month weight-reduction program positively alters body composition, aerobic fitness and habitual physical activity of severely obese girls: a pilot evaluation study. J Sports Sci. 2010. 28(3):281-9.
C. Aguer, J. Mercier, M. Kitzmann.Lipid content and response to insulin are not invariably linked in human muscle cells. Mol Cell Endocrinol. 2010. 315(1-2):225-32.
S. Bordenave, C. Aguer, M. Kitzmann, J. Mercier. Physical exercise and insulin resistance: from muscle metabolic physiopathology to therapeutics. J Soc Biol. 2007. 201(2):149-54.
K. Lambert, C. Aguer, M. Kitzmann, A. Mannarino, C. Fédou, E. Raynaud De Mauverger, J. Mercier, J-F. Brun. Whole-body lipid oxidation during exercise is correlated to insulin sensitivity and mitochondrial function in middle-aged obese men. Austin Diabetes Research. Accepted, May 16th, 2017